Organoids are miniature, three-dimensional structures grown from stem cells that replicate key features of human organs. They represent powerful 3D models that replicate human tissue complexity, unlocking innovative applications in both drug discovery and therapeutics. As illustrated below, organoids enable high-precision research in disease modeling, toxicity testing, and regenerative strategies.
Organoids provide a realistic model for studying diseases in a 3D context. They also serve as models to study host-pathogen interactions, offering insights into how infections develop and progress.
Organoids provide a powerful model system for high-throughput drug screening in a physiologically relevant context. They improve the accuracy of efficacy and toxicity predictions, reduce reliance on animal models, and streamline early-stage drug development.
Organoids derived from patient-specific tissues will enable personalized medicine by reflecting individual genetic, pathological, and treatment response profiles. They would allow clinicians to test therapeutic options on patient-derived models, potentially improving treatment selection and outcomes.
Organoids will offer new solutions in regenerative medicine by serving as therapeutic bioengineered tissue. Their ability to mimic native tissue architecture and function holds potential for repairing damaged organs, restoring physiological functions, or supporting transplantation.
Organoids are used extensively to study developmental biology, tissue homeostasis, biomarker discovery and cellular differentiation, contributing to the advancement of biomedical sciences
Extracellular vesicles are nano-sized particles naturally released by cells, carrying proteins, nucleic acids, and other bioactive molecules. Extracellular vesicles are explored for their therapeutic potential and biotechnological development. As the image illustrates, extracellular vesicles support diverse applications—from drug delivery and regenerative medicine to biomarker discovery, vaccine design, and advanced diagnostics.
Extracellular vesicles have the potential to serve as biomarkers, for disease diagnosis, disease prognosis or treatment monitoring.
The engineering of extracellular vesicles to express antigens of interest has emerged as a novel approach for vaccine development.
Extracellular vesicles can play a key role in regenerative medicine by delivering bioactive molecules that can modulate dysregulated physiological processes.
Extracellular vesicles have emerged as a promising vehicle for drug delivery due to their intrinsic capacity to facilitate the transfer of biomolecules between cells. They can be engineered to carry therapeutic agents, such as drugs, nucleic acids, proteins, and to target cells, enhancing treatment specificity and reducing off-target effects.
